Uma Karuna Thurman

With a successful film career, Thurman once again became a desired model. Cosmetics company Lancôme selected her as its spokeswoman. It also named several shades of lipstick after her, though they were sold only in Asia. In 2005, Thurman became a spokeswoman for the French fashion house Louis Vuitton. On February 7, 2006, she was also named a knight of the Ordre des Arts et des Lettres of France for outstanding achievement in the field of art and literature.
In May 2006, Thurman bought the film rights to the Frank Schätzing novel The Swarm, which is in development and due for release in 2015. When the film remake The Women was in pre-production in 2006, Thurman was cast as Crystal Allen, alongside Annette Bening, Julia Roberts, Meg Ryan, Sandra Bullock, Ashley Judd, Lisa Kudrow and Anne Hathaway, being directed by James L. Brooks, but the director was changed and Thurman was no longer part of the cast. In July 2006, she starred opposite Luke Wilson in My Super Ex-Girlfriend. Thurman portrayed a super-heroine named "G-Girl" who is dumped by her boyfriend and then takes her revenge upon him. She received a reported $14 million for the role, but the film flopped. Once again she was well-received, but the film was not.
In February 2008, she starred opposite Colin Firth and Jeffrey Dean Morgan in The Accidental Husband, a romantic comedy about a woman who finds herself married while engaged to another man. It seems like archetypal Hollywood contrivance, but according to Thurman, a similar situation happened in New York. Also in 2008, she starred as Elsa in the British film My Zinc Bed, in which she plays a cocaine addict, starring opposite Paddy Considine and Jonathan Pryce. In 2010, her movie Motherhood, set a record for the biggest bomb in British cinema history garnering just £88 on 11 tickets on its opening weekend. In the United States it earned just $93,388 in three weeks of release.
In 2011, Thurman was a member of the jury for the main competition at the Cannes Film Festival. In December 2011, James Hibberd of Entertainment Weekly reported Thurman had joined the cast of NBC's Smash as Rebecca Duvall. Thurman will appear in five episodes of the drama series. For her portrayal of Duvall, Thurman was nominated for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series.